News

18
Mar , 2025

Connectional axis of individual functional variability: Patterns, structural correlates, and relevance for development and cognition

We published a research article in PNAS, revealing the spatial organization of functional connectivity variability across the human connectome edges and its significance in cognitive development. We published a research article in PNAS, revealing the spatial organization of functional connectivity variability across the human connectome edges and its significance in cognitive development. We identify a stable axis on functional connectome along which connectivity variability continuously varies, aligning with structural connectivity variability. We find that the pattern of this axis evolves during development, marked by a decrease in functional connectivity variability among association connections. Moreover, the variability axis is associated with individual differences in higher-order cognitions, driven by increased variability in higher-order association connections linked to enhanced cognitive performance. Congratulations to Hang Yang and Guowei Wu. Thanks to all the collaborators who contributed to the work, especially the support from Xiaoyu Xu, Jing Cong and Haoshu Xu. Check here for more information: www.pnas.org/doi/10.1073/pnas.2420228122.


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