News

11
May , 2026

Long-range white-matter pathways enable efficient spontaneous propagation in the human brain

We published a research article "Long-range white-matter pathways enable efficient spontaneous propagation in the human brain" in The Journal of Neuroscience. By integrating stereo-EEG with diffusion spectrum imaging, this study shows that brain-wide information propagation is not determined by distance alone, but is critically supported by long-range white-matter pathways, their microstructural properties, and intrinsic functional network organization. We also find that both pathological epileptiform discharges and physiological spontaneous activity follow shared propagation rules, exhibiting distance saturation, structural facilitation, and preferential within-network transmission. These findings provide a microstructure-grounded account of how the human brain achieves fast, efficient large-scale communication, bridging macroscale connectome architecture with millisecond-scale neural dynamics. Congratulations to Longzhou Xu. Thanks to all the collaborators who contributed to the work, especially the support from Shen Zhang. We are also deeply grateful to the neurosurgeons from Xuanwu Hospital, Capital Medical University, for providing the invaluable stereo-EEG data essential to this research. Read the full article: https://www.jneurosci.org/content/early/2026/05/05/JNEUROSCI.0039-26.2026.


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