We have published a research article in Brain Stimulation, marking our group’s debut in the field of neuromodulation research. This study is the first to comprehensively and quantitatively explore the safety of 1064 nm laser transcranial photobiomodulation (tPBM).  To investigate the safety of 1064 nm laser tPBM, we employed multidimensional and quantitative approaches, including measurements of serum neurobiomarkers such as NSE and S100β, electroencephalogram (EEG) and magnetic resonance imaging (MRI) scans, assessments of executive functions, and subjective questionnaires. Across all five dimensions, 1064 nm laser tPBM showed no evidence of harm. Our findings demonstrate that tPBM is well-tolerated, causing no noise, pain, or burning sensations, making it particularly suitable for populations with low tolerance. These results hold significant implications for ethical approvals of tPBM-related research and its application in low-tolerance populations, particularly in children and adolescents. Congratulations to Zhilin. Thanks to our collaborators from Qilu Hospital. You can check the paper at: https://doi.org/10.1016/j.brs.2024.11.010